We attend to create a future molecular scaffold, with which highly efficient and selective chloride ion transportation will be feasible. Supramolecular chemistry derived polyamide protein mimetics were developed with various structural and functional properties. However, such construct were not used for the transportation of ions through membranes. We aim to design and synthetize artificial proteomimetic chloride ion transporters. Design of supramolecular artificial transporter constructs is expected to deepen our understanding of the fundamental insight into unnatural transporter assemblies. From a practical perspective, we aim to arrive to a general molecular scaffold possessing specific chloride ion transportation activity, which can later be further developed to maximize its efficiency in various diseases like cystic fibrosis, or can be utilized in oncology or central nervous system therapy. Such systems might have strong drug development potential.

The alteration of the chloride ion transportation by artificial (membrane inserted) transporter can give further insight into the ion balance of various cells. It may provide further understandings into the pathomechanism and potential treatment of cystic fibrosis and into some oncological and neurobiological cases.


István Mándity