A Peptidalapú Vakcinák Kutatócsoport 2021-ben alakult az MTA Lendület Programjának támogatásával. A csoportban előállított peptideket, peptid-származékokat és konjugátumokat különböző kutatási területeken alkalmazzuk. A szintetikus peptidek biológiai hatásának fokozására és stabilitásuk megőrzésére új formulációs stratégiákat dolgozunk ki. Kolloidkémiai rendszerek segítségével peptidhordozó platformokat fejlesztünk, melyek számos előnyös tulajdonsággal rendelkeznek, mint a célbajuttatás, programozott hatóanyag-leadás és fokozott immunogenitás.
Fő kutatási témák:
– Szintetikus vakcinák
– Dendritikus sejtek célzása peptidekkel
– Antimikrobiális peptidek és peptid-származékok
– Szintetikus vakcinák az immunterápiában
– Melanoma specifikus peptidek és peptid-származékok
A Biological Soft Matter Platform honlapja
Vezető
Horváti Kata
Publikációk:
2025
Chakraborty S., el Battioui K., Sonallya T., Szigyártó I.C., Horváti K., Varga Z., Juhász T., Beke-Somfai T.: Charge and length dependent build-up of environment sensitive lamellin β-peptides (2025) Physical Chemistry Chemical Physics, 27 (16), pp. 8540 – 8551. DOI: 10.1039/d4cp04561k [IF(2024):2.9] Q1
Fecske, D.; Kasza, Gy.; Gyulai, G.; Horváti, K.; Szabó, M.; Wacha, A.; Varga, Z.; Szarka, Gy.; Thomann, Y.; Thomann, R.; Mülhaupt, R.; Kiss, É.; Domján, A.; Bősze, Sz.; Bereczki, L.; Iván, B.
Self-Assembling Amphiphilic ABA Triblock Copolymers of Hyperbranched Polyglycerol with Poly(tetrahydrofuran) and Their Nanomicelles as Highly Efficient Solubilization and Delivery Systems of Curcumin. Int. J. Mol. Sci. (2025), 26, 5866. [IF(2023):4.9]
Chiara Bellini, Unai Atxabal, Szilvia Bősze, Orsolya Dobay, Andrea Horváth, Imola Cs. Szigyártó, Tamás Beke-Somfai, Jesús Jiménez-Barbero, István Puskás, Kata Horváti*: Supramolecular complexes of ultrashort cationic lipopeptides with cyclodextrins: improved selectivity and therapeutic potential. Aggregate (2025) 0:e741; https://doi.org/10.1002/agt2.7411 [IF(2023):13.9] D1
2024
Ágnes Ábrahám, Gergő Gyulai, Judith Mihály, Andrea Horváth, Orsolya Dobay, Zoltán Varga, Éva Kiss, Kata Horváti*: Optimizing lipopeptide bioactivity: The impact of non-ionic surfactant dressing, J Pharm Anal. (2024) 101020, https://doi.org/10.1016/j.jpha.2024.101020. [IF:8.9] D1
El Battioui K, Chakraborty S, Wacha A, Molnár D, Quemé-Peña M, Szigyártó IC, Szabó CL, Bodor A, Horváti K, … Beke-Somfai T. In situ captured antibacterial action of membrane-incising peptide lamellae. Nat Commun. (2024) 15(1):3424. doi: 10.1038/s41467-024-47708-4. [IF(2023):14.7] D1
György Kasza, Ákos Fábián, Dóra Fecske, Attila Kardos, Róbert Mészáros, Kata Horváti, Béla Iván. Hyperbranched polyglycerol grafted poly(N,N-diethylacrylamide) thermoresponsive copolymers as biocompatible, highly efficient encapsulation and sustained release systems of curcumin. Eur Polymer J (2024) 219:113378. https://doi.org/10.1016/j.eurpolymj.2024.113378. [IF:6.3] Q1
Humer C, Radiskovic T, Horváti K, Lindinger S, Groschner K, Romanin C, Höglinger C: Bidirectional allosteric coupling between PIP2 binding and the pore of the oncochannel TRPV6. Int. J. Mol. Sci. (2024), 25(1), 618; https://doi.org/10.3390/ijms25010618 [IF:4.9] Q1
2023
Bellini C, Vergara E, Bencs F, Fodor K, Bősze S, Krivić D, Bacsa B, Surguta SE, Tóvári J, Reljic R, Horváti K*. Design and characterization of a multistage peptide-based vaccine platform to target Mycobacterium tuberculosis infection. Bioconjug Chem. (2023) 34:1738-1753. [IF:6.069] D1
Tóth G, Horváti K, Kraszni M, Ausbüttel T, Pályi B, Kis Z, Mucsi Z, Kovács G M, Bősze Sz, Boldizsár I. Arylnaphthalene lignans with anti-SARS-CoV-2 and antiproliferative activities from the underground organs of Linum austriacum and Linum perenne. J Nat Prod (2023) 86(4): 672–682 [IF:4.803] Q1
2021
Horváti K, Fodor K, Pályi B, Henczkó J, Balka Gy, Gyulai G, Kiss É, Biri-Kovács B, Senoner Zs, Bősze Sz. Novel assay platform to evaluate intracellular killing of Mycobacterium tuberculosis: in vitro and in vivo validation. Front Immunol. (2021) 12:750496. doi: 10.3389/fimmu.2021.750496 [IF: 8.786] Q1
Juhász T, Quemé-Peña M, Kővágó B, Mihály J, Ricci M, Horváti K, Bősze S, Zsila F, Beke-Somfai T. Interplay between membrane active host defense peptides and heme modulates their assemblies and in vitro activity. Sci Rep. (2021) 11(1):18328. [IF: 4.996] Q1
Farkas V, Ferentzi K, Horváti K, Perczel A. Cost-Effective Flow Peptide Synthesis: Metamorphosis of HPLC. Org. Process Res. Dev. (2021) 25(2) 182–191 [IF: 3.858] (independent citations: 1)
Zürn M, Tóth G, Ausbüttel T, Mucsi Z, Horváti K, Bősze Sz, Sütöri-Diószegi M, Pályi B, Kis Z, Noszál B, Boldizsár I. (2021) Tissue specific accumulation and isomerization of valuable phenylethanoid glycosides from Plantago and Forsythia plants. Int. J. Mol. Sci. 2021, 22(8), 3880 [IF(2010): 5.924] Q1
Kósa N, Zolcsák Á, Voszka I, Csík G, Horváti K, Horváth L, Bősze Sz, Herenyi L. (2021) Comparison of the efficacy of two novel antitubercular agents in free and liposome-encapsulated formulations. Int. J. Mol. Sci. 2021, 22(5), 2457 [IF: 6.208] Q1
Quemé-Peña M, Ricci M, Juhász T, Horváti K, Bősze S, Biri-Kovács B, Szereder B, Zsila F, Beke-Somfai T. (2021) Old Polyanionic Drug Suramin Suppresses Detrimental Cytotoxicity of the Host Defense Peptide LL-37. ACS Pharmacol. Transl. Sci. 4(1) 155–167
2020
Bellini C, Horváti K*. Recent advances in the development of protein- and peptide-based subunit vaccines against tuberculosis. Cells 2020, 9(12), 2673; https://doi.org/10.3390/cells9122673. [IF: 6.600]
Pári E, Horváti K, Bősze S, Biri-Kovács B, Szeder B, Zsila F, Kiss É. Drug Conjugation Induced Modulation of Structural and Membrane Interaction Features of Cationic Cell-Permeable Peptides. Int J Mol Sci. 2020 21(6). pii: E2197. doi: 10.3390/ijms21062197. [IF: 5.924]
Ricci M, Horváti K, Juhász T, Szigyártó I, Török Gy, Sebák F, Bodor A, Homolya L, Henczkó J, Pályi B, Mlinkó T, Mihály J, Nizami1 B, Yang Z, Lin F, Lu X, Románszki L, Bóta A, Varga Z, Bősze Sz, Zsila F, Beke-Somfai T. (2020) Anionic food color Tartrazine enhances antibacterial efficacy of Histatin-derived peptide DHVAR4 by fine-tuning its membrane activity. Quarterly Rev Biophysics 53, e5, 1–11. https:// doi.org/10.1017/S0033583520000013 [IF:5.318]
2019
Horváti K*, Pályi B, Henczkó J, Balka Gy, Szabó E, Farkas V, Biri-Kovács B, Szeder B, Fodor K. (2019) A convenient synthetic method to improve immunogenicity of Mycobacterium tuberculosis related T-cell epitope peptides. Vaccines 7(3), 101. [IF:4.086]
Zürn M, Tóth G, Mazákné Kraszni M, Sólyomváry A, Mucsi Z, Deme R, Rózsa B, Fodor B, Molnár-Perl I, Horváti K, Bősze Sz, Pályi B, Kis Z, Béni Sz, Noszál B, Boldizsár I. (2019) Galls of European Fraxinus trees as new and abundant sources of valuable phenylethanoid and coumarin glycosides. Industrial Crops and Products 139: 111517-26 [IF: 4.244]
Gyulai G., Ouanzi F., Bertóti I., Mohai M., Kolonits T., Horváti K., Bősze S. Chemical structure and in vitro cellular uptake of luminescent carbon quantum dots prepared by solvothermal and microwave assisted techniques. J. Colloid Interface Sci. 2019, 549, 150-161. [IF: 7.361]
Quemé-Peña M, Juhász T, Mihály J, Szigyártó IC, Horváti K, Bősze S, Henczkó J, Pályi B, Németh C, Varga Z, Zsila F, Beke-Somfai T. (2019) Manipulating active structure and function of cationic antimicrobial peptide CM15 by the polysulfonated drug suramin: a step closer to in vivo complexity. ChemBioChem 20:1–14 [IF: 2.576]
2018
Ábrányi-Balogh P, Petri L, Imre T, Szijj P, Scarpino A, Hrast M, Mitrovic A, Fonovic UP, Németh K, Barreteau H, Roper DI, Horváti K, Ferenczy GyG, Kos J, Ilas J, Gobec S, Keserű GyM. (2018) A road map for prioritizing warheads for cysteine targeting covalent inhibitors. Eur J Med Chem. 2018. 160:94-107 [IF: 4.816]
Kiss É, Gyulai G, Pári E, Horváti K, Bősze S. (2018) Membrane affinity and fluorescent labelling: comparative study of monolayer interaction, cellular uptake and cytotoxicity profile of carboxyfluorescein-conjugated cationic peptides. Amino Acids 50(11):1557-1571 [IF: 2.906]
Horváti K, Gyulai G, Csámpai A, Rohonczy J, Kiss É, Bősze Sz (2018) Surface layer modification of PLGA nanoparticles with targeting peptide: a convenient synthetic route for Pluronic F127 – Tuftsin conjugate. Bioconjugate Chem. 29(5):1495-1499 [IF: 4.818]
Zsila F, Juhász T, Bősze Sz, Horváti K, Beke-Somfai T (2018) Hemin and bile pigments are the secondary structure regulators of intrinsically disordered antimicrobial peptides. Chirality 30(2):195-205. [IF: 1.956]
Sipka S, Papp Zs, Kovács I, Horváti K, Bősze Sz, Hudecz F, Szilasi M (2018) Index of stimulation and TNFα measurements used for laboratory diagnosis of latent Tuberculosis as a new principle. Int J Pulmonol Infect Dis.1(2):1-5.
2017
Horváti K, Bacsa B, Mlinkó T, Szabó N, Hudecz F, Zsila F, Bősze Sz (2017) Comparative analysis of internalisation, haemolytic, cytotoxic and antibacterial effect of membrane-active cationic peptides: aspects of experimental setup. Amino Acids. 49(6):1053-1067. [IF: 2.906]
Zsila F, Bősze Sz, Horváti K, Szigyártó CsI, Beke-Somfai T (2017) Drug and dye binding induced folding of the intrinsically disordered antimicrobial peptide CM15. RSC Advances 7:41091-41097. [IF: 2.936]
2016
Ábrahám Á, Baranyai Zs, Gyulai G, Pári E, Horváti K, Bősze Sz, Kiss É (2016) Comparative analysis of new peptide conjugates of antitubercular drug candidates-model membrane and in vitro studies. Colloids Surf B Biointerfaces. 28(147):106-115. [IF: 3.887]
Horvati K, Bősze Sz, Gideon HP, Bacsa B, Szabó TG, Goliath R, Rangaka MX, Hudecz F, Wilkinson RJ, Wilkinson KA (2016) Population tailored modification of tuberculosis specific interferon-gamma release assay. J Infection 72:179-188. [IF: 4.201]
2015
Horváti K, Bacsa B, Szabó N, Fodor K, Balka G, Rusvai M, Kiss É, Mező G, Grolmusz V, Vértessy B, Hudecz F, Bősze Sz (2015) Antimycobacterial activity of peptide conjugate of pyridopyrimidine derivative against Mycobacterium tuberculosis in a series of in vitro and in vivo models. Tuberculosis: 95:S207-211. [IF: 2.952]
Baranyai Zs, Krátký M, Vinšová J, N Szabó N, Senoner Zs, Horváti K, Stolaříková J, Dávid S, Bősze Sz (2015) Combating highly resistant emerging pathogen Mycobacterium abscessus and Mycobacterium tuberculosis with novel salicylanilide esters and carbamates, Eur J Med Chem 101:692-704. [IF: 3.902]
2014
Horváti K, Bacsa B, Kiss E, Gyulai G, Fodor K, Balka G, Rusvai M, Szabó E, Hudecz F, Bősze Sz (2014) Nanoparticle encapsulated lipopeptide conjugate of antitubercular drug isoniazid: in vitro intracellular activity and in vivo efficacy in a Guinea pig model of tuberculosis. Bioconjug Chem. 25(12):2260-2268. [IF: 4.513]
Kiss É, Gyulai G, Pénzes CB, Idei M, Horváti K, Bacsa B, Bősze Sz (2014) Tunable surface modification of PLGA nanoparticles carrying new antitubercular drug candidate. Colloid Surface A. 458: 178-186. [IF: 2.752]
Cserép GB, Baranyai Z, Komáromy D, Horváti K, Bősze Sz, Kele P (2014) Fluorogenic tagging of peptides via Cys residues using thiol-specific vinyl sulfone affinity tags. Tetrahedron 70(35): 5961-5965. [IF: 2.641]
2013
Misják P, Bősze Sz, Horváti K, Pasztói M, Palóczi K, Holub MC, Szakács F, Aradi B, György B, Szabó TG, Nagy G, Glant TT, Mikecz K, Falus A, Buzás EI (2013) The role of citrullination of an immunodominant proteoglycan (PG) aggrecan T cell epitope in BALB/c mice with PG-induced arthritis. Immunol Lett. 152: 25-31. [IF: 2.367]
2012
Horváti K, Bacsa B, Szabó N, Dávid S, Mező G, Grolmusz V, Vértessy B, Hudecz F, Bősze Sz (2012) Enhanced cellular uptake of a new, in silico identified antitubercular candidate by peptide conjugation. Bioconjug Chem. 23: 900-907. [IF: 4.580]
Pénzes CB, Schnoller D, Horváti K, Bősze Sz, Mező G, Kiss É (2012) Membrane affinity of antituberculotic drug conjugate using lipid monolayer containing mycolic acid. Colloid Surfaces A. 413: 142-148. [IF: 2.108]
2011
Vavrikova E, Polanc S, Kocevar M, Kosmrlj J, Horvati K, Bősze Sz, Stolarikova J, Imramovsky A, Vinsova J (2011) New series of isoniazid hydrazones linked with electron-withdrawing substituents. Eur J Med Chem. 46: 5902-5909. [IF: 3.346]
Vavrikova E, Polanc S, Kocevar M, Horváti K, Bősze Sz, Stolarikova J, Vavrova K, Vinsova J (2011) New fluorine-containing hydrazones active against MDR-tuberculosis. Eur J Med Chem. 46: 4937-4945. [IF: 3.346]
Vavrikova E, Mandikova J, Trejtnar F, Horváti K, Bősze Sz, Stolarikova J, Vinsova J (2011) Cytotoxicity decreasing effect and antimycobacterial activity of chitosan conjugated with antituberculotic drugs. Carbohyd Polym. 83: 1901-1907. [IF: 3.628]
Schnöller D, Pénzes CB, Horváti K, Bősze Sz, Hudecz F, Kiss É (2011) Membrane affinity of new antitubercular drug candidates using a phospholipid Langmuir monolayer model and LB technique. Prog Colloid Polym Sci. 138: 131-138. [IF: 2.331]
Kiss É, Schnöller D, Pribranska K, Hill K, Pénzes CB, Horváti K, Bősze Sz (2011) Nanoencapsulation of antitubercular drug isoniazid and its lipopeptide conjugate. J Disper Sci Technol. 32: 1728-1734. [IF: 0.560]
2010
Kratky M, Vinsova J, Buchta V, Horváti K, Bősze Sz, Stolarikova J (2010) New amino acid esters of salicylanilides active against MDR-TB and other microbes. Eur J Med Chem. 45: 6106-6113. [IF: 3.193]
Hill K, Pénzes CB, Schnöller D, Horváti K, Bősze Sz, Hudecz F, Keszthelyi T, Kiss É (2010) Characterisation of the membrane affinity of an isoniazide peptide conjugate by tensiometry, atomic force microscopy and sum-frequency vibrational spectroscopy, using a phospholipid Langmuir monolayer model. Phys Chem Chem Phys. 12: 11498-11506. [IF: 3.453]
2009
Horváti K, Mező G, Szabó N, Hudecz F, Bősze Sz (2009) Peptide conjugates of therapeutically used antitubercular isoniazid-design, synthesis and antimycobacterial effect. J Pept Sci. 15: 385-391. [IF: 1.807]
Balogh Á, Horváti K, Mező G, Derzbach L, Szebeni B, Nagy L, Prechl J, Vásárhelyi B, Hudecz F, Bősze Sz (2009) Synthesis of hepcidin derivatives in order to develop standards for immune adsorption method. J Pept Sci. 15: 285-295. [IF: 1.807]
2008
Manea M, Kalászi A, Mező G, Horváti K, Bodor A, Horváth A, Farkas Ö, Perczel A, Przybylski M, Hudecz F. (2008) Antibody recognition and conformational flexibility of a plaque-specific beta-amyloid epitope modulated by non-native peptide flanking regions. J Med Chem. 51: 1150-1161. [IF: 4.898]
Horváti K, Bősze Sz, Hudecz F, Medzihradszky-Schweiger H (2008) A simple method for monitoring the cysteine content in synthetic peptides. J Pept Sci. 14: 838-844. [IF: 1.654]
Bacsa B, Horváti K, Bősze S, Andreae F, Kappe CO (2008) Solid-phase synthesis of difficult peptide sequences at elevated temperatures: a critical comparison of microwave and conventional heating technologies. J Org Chem. 73: 7532-7542. [IF: 3.952]
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