More information about the research group: www.biostruct.org

Group leader

Vértessy G. Beáta – Google Scholar

Principal Investigators

Judit Tóth

Angéla Békési

Junior Principal Investigators

Kinga Nyiri

Rita Hirmondó

Gergely Nándor Nagy

Members

András Benedek

Hajnalka Pálinkás

Ibolya Leveles

Nagy Kinga

Zsófia Molnár

PhD Students

Dániel Molnár

Nikolett Nagy

Richard Izrael

Réka Babai

Zoé Tóth

Otília Tóth

Viktória Perey-Simon

Eszter Holub

Telek András

Askar Kholikov

Undergraduate Students

Gábor Papp

Kun Zsuzsa

Sütő Panna

Molnár Blanka

Laura Bukovszki

Réka Iván

Márk Hegedüs

Anna Felföldi

Dániel Dombóvári

Administration

Éva Tankó

Hajnalka Németh

Selected recent publications:

  • Berta D, Gehrke S, Nyíri K, Vértessy BG, Rosta E.
    Mechanism-Based Redesign of GAP to Activate Oncogenic Ras.
    J Am Chem Soc. 2023 Sep 20;145(37):20302-20310. doi: 10.1021/jacs.3c04330.
  • Pálinkás HL, Békési A, Róna G, et al, Vértessy BG.
    Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments.
    Elife. 2020 Sep 21;9:e60498. doi: 10.7554/eLife.60498.
  • Babai R, Izrael R, Vértessy BG.
    Characterization of the dynamics of Plasmodium falciparum deoxynucleotide-triphosphate pool in a stage-specific manner.
    Sci Rep. 2022 Nov 19;12(1):19926. doi: 10.1038/s41598-022-23807-4.
  • Pancsa R, Fichó E, Molnár D, et al Tóth J.
    dNTPpoolDB: a manually curated database of experimentally determined dNTP pools and pool changes in biological samples.
    Nucleic Acids Res. 2022 Jan 7;50(D1):D1508-D1514. doi: 10.1093/nar/gkab910.
  • Szabó JE, Surányi ÉV, Mébold BS, Trombitás T, Cserepes M, Tóth J.
    A user-friendly, high-throughput tool for the precise fluorescent quantification of deoxyribonucleoside triphosphates from biological samples.
    Nucleic Acids Res. 2020 May 7;48(8):e45. doi: 10.1093/nar/gkaa116.
  • Nyíri K, Koppány G, Vértessy BG.
    Structure-based inhibitor design of mutant RAS proteins-a paradigm shift.
    Cancer Metastasis Rev. 2020 Dec;39(4):1091-1105. doi: 10.1007/s10555-020-09914-6.
  • Rácz GA, Nagy N, Tóvári J, Apáti Á, Vértessy BG.
    Identification of new reference genes with stable expression patterns for gene expression studies using human cancer and normal cell lines.
    Sci Rep. 2021 Sep 30;11(1):19459. doi:10.1038/s41598-021-98869-x.
  • Pálinkás HL, Pongor L, Balajti M, et al Vértessy BG, Győrffy B.
    Primary Founder Mutations in the PRKDC Gene Increase Tumor Mutation Load in Colorectal Cancer.
    Int J Mol Sci. 2022 Jan 6;23(2):633. doi: 10.3390/ijms23020633.
  • Cserepes M, Türk D, Tóth S, Pape VFS, Gaál A, Gera M, Szabó JE, Kucsma N, Várady G, Vértessy BG, Streli C, Szabó PT, Tovari J, Szoboszlai N, Szakács G.
    Unshielding Multidrug Resistant Cancer through Selective Iron Depletion of P-Glycoprotein-Expressing Cells.
    Cancer Res. 2020 Feb 15;80(4):663-674. doi:10.1158/0008-5472.CAN-19-1407.
  • Nyíri K, Mertens HDT, Tihanyi B, et al Vértessy BG.
    Structural model of human dUTPase in complex with a novel proteinaceous inhibitor.
    Sci Rep. 2018 Mar 12;8(1):4326. doi:10.1038/s41598-018-22145-8.

Graduated PhD students in the last 10 years:

Molnár Petra Andrea PhD, 2021

Benedek András PhD, 2020

Pálinkás Hajnalka Laura PhD, 2020

Surányi Éva Viola PhD, 2020

Nagy Kinga PhD, 2019

Papp-Kádár Veronika PhD, 2019

Marton Lívia PhD, 2018

Nyíri Kinga PhD, 2018

Scheer Ildikó Zsófia PhD, 2017

Nagy Gergely Nándor PhD, 2015

Róna Gergely PhD, 2015

Horváth András PhD, 2013

Szabó Judit Eszter PhD, 2016

Váradiné Hirmondó Rita PhD, 2016

Current collaborations

International collaborations

  • Medical University of Vienna, Center for Cancer Research (Gergely Szakács)
  • Queen’s University Belfast, School of Medicine, Dentistry and Biomedical Sciences, Patrick G Johnston Centre for Cancer Research, Belfast UK (Melissa LaBonte Wilson)
  • Cornell University, Division of Nutritional Sciences , New York US (Martha Field)
  • University of Massachusetts Department of Biology, Boston US (Shailja Pathania)
  • University of Toronto, Department of Biochemistry, Toronto Canada (Grant Brown)
  • Laboratory of Pathogens and Host Immunity, University of Montpellier, France (Kai Wengelnik, Rachel Cerdan)
  • University College London, UK (Edina Rosta)
  • Henrik Clausen Copenhagen Centre for Glycomics, Denmark (Rebecca L. Miller)
  • University of Oxford, UK (E. Yvonne Jones)

Hungarian collaborations

  • Biomolecular Self-assembly Research Group, Institute of Materials and Environmental Chemistry, HUN-REN RCNS
  • Genome Stability Research Group, Institute of Molecular Life Sciences, HUN-REN RCNS
  • Drug Resistance Research Group, Institute of Molecular Life Sciences, HUN-REN RCNS
  • Epigenetic and Genome Editing Research Group, Institute of Molecular Life Sciences, HUN-REN RCNS
  • Protein Bioinformatics Research Group, Institute of Molecular Life Sciences, HUN-REN RCNS
  • Glycan Biomarker Research, Group, Institute of Organic Chemistry, HUN-REN RCNS
  • Department of Internal Medicine and Oncology, Semmelweis University, Faculty of Medicine
  • 3DHISTECH Ltd.
  • Servier
  • Dr. Bata Ltd.

Members